About CBD
Our body has an endocannabinoid system made up of cannabinoid receptors. This system helps regulate our sense of pain, mood, appetite, etc. Many of the effects of cannabinoids are mediated by two receptors (linked to G proteins-GPCR), CB (1) and CB (2). The CB (1) receptors are present in high proportions in some parts of the brain. These receptors mediate many of the effects of cannabinoids. CB (2) receptors have a limited distribution, located in some neurons. Without these receptors, we would not feel any effects of cannabinoids. Although each of us has an endocannabinoid system in our body, the effects of cannabinoids vary from individual to individual, with a similar course.
Endocannabinoids support many vital functions in the body, including the immune system, and also regulate food intake to a certain extent. They help the body to balance out the physiological, biochemical and psychological stress that humans are exposed to in their environment. They have a positive effect on people’s ability to learn and process new information. Similar to the immune system, endocannabinoids also protect the body from protein-based attacks.
The basic cannabinoid is cannabigerolic acid – CBGA. Also called the ancestor of cannabinoids. CBGA is transformed during the growth of the cannabis plant into other known cannabinoids that act on the CB (1) and CB (2) receptors. Cannabinoids are compounds that occur naturally in the Cannabis sativa plant.
Of the more than 480 different compounds found in the plant, about 120 are cannabinoids:
- CBD – cannabidiol
- CBG – cannabigerol
- CBC – cannabichromenes
- CBN – cannabinol
- CBDL – cannabinodiol
- CBL – cannabicyclol
- CBE – cannabielsoin
- CBT – cannabitriol
- THC –
- tetrahydrocannabinol
All cannabinoids are created through the action of certain enzymes, where CBGA is converted into THCA , CBDA, CBCA and CBG . These enzymes are called acid synthesis. This occurs when the plant is heated or dried.
CBGA is at the forefront of the cascade reaction that produces the three main cannabinoid lineages and CBG:
CBGA is the "ancestor" of all other cannabinoids in cannabis. The ability to produce CBGA makes cannabis a truly excellent plant. Cannabigerolic acid is the precursor for all three main acids, which gradually become the three main cannabinoids through the influence of heat or light.
- THCA – tetrahydrocannbinoleic acid
- CBDA – cannabidiolic acid
- CBCA – cannabichromenic acid
- CBG – Cannabigerol
These then become THC, CBD, or CBC. CBGA can also be converted to CBG , but in most strains, CBGA is ultimately converted to THC or CBD. Let's look at the skin cannabinoids and their effects based on many scientific researches and laboratory tests.
CBD - Cannabidiol
Scientific studies have shown that CBD can provide relief from many different diseases and symptoms , and while CBD is considered controversial or misunderstood, it is important to realize that CBD is perfectly safe for human use as it does not contain any addictive cannabinoids or other substances. Some properties of CBD.
- Relieves chronic pain and inflammation
- Calms or stops epilepsy
- Eliminates oxidative stress – this health problem is relatively new due to increased environmental toxicity around the world.
- Regulates blood pressure, therefore CBD can be used as a preventative measure for a healthy heart.
- Fights against multi-resistant bacteria, is bactericidal against staphylococci and streptococci strains.
- Can also regulate excess sebum, which can help prevent acne
- In full spectrum form, it helps with insomnia, improves sleep quality and regenerates the organism.
- Antispasmodic properties help with acute muscle cramps, relax and regenerate muscles after strenuous exercise.
- Antidepressant and anti-anxiety properties have also been demonstrated. Effective against depression, mental tension and anxiety .
Cannabidiol is now legal in Europe and the UK and in all EU countries. The legal requirement is that it is extracted exclusively from cannabis plants and not from marijuana. EU regulations state that CBG products with a THC content of more than 0.2% are illegal if smoking marijuana is not legal in that particular country.
CBG - Cannabigerol
The health benefits of CBG have still not been fully researched. However, initial research suggests that CBG may be a useful tool in treating a wide range of physical and mental health issues. Let's look at the existing research on CBG and its potential positive effects on our health.
- Anti-inflammatory effects – potentially CBG could help in the treatment of many different and chronic inflammatory diseases
- Reduces inflammatory markers of gastrointestinal diseases (IBD)
- Effective against inflammatory skin diseases and diseases of internal organs
- Helps in the treatment of colitis, arthritis, hypertension, heart disease, diabetes, depression
- Can also act as an antioxidant and protects the nervous system from damage
- Antimicrobial effects
- Stimulates the appetite
- Helps with bladder problems
- Stimulant of bone growth. Helps in the healing of bone fractures and other injuries of the musculoskeletal system
Cannabigerol is now legal in Europe and the UK and in all EU countries. The legal requirement is that it is extracted exclusively from cannabis plants and not from marijuana. EU regulations state that CBG products with a THC content of more than 0.2% are illegal if smoking marijuana is not legal in the country in question.
CBC - Cannabichromen
Available scientific research proves that this non-psychoactive cannabinoid can have very strong antibacterial, analgesic and anti-inflammatory effects. CBC, like any known cannabinoid, has no healing effect on its own. Its synergistic effect with other cannabinoids could have much broader and more effective effects than the cannabinoid itself. Therefore, there is a reason to attract the attention of scientists and the public and to look at the hemp plant as a whole.
- Relieves depression, mental tension and anxiety
- Antibacterial, anti-inflammatory and antifungal properties – works without activating the cannabinoid receptors in our body
- Relieves pain without altering consciousness
- Proven positive effect of CBC in the prevention and treatment of dysfunction of intestinal peristalsis (ie insufficient intestinal motility)
- It also plays an important role in the treatment of bacterial infections and viral infections
Cannabichromene is now legal in Europe and the UK and in all EU countries. The legal requirement is that it is extracted exclusively from cannabis plants and not from marijuana. EU regulations state that CBG products with a THC content of more than 0.2% are illegal if smoking marijuana is not legal in the country in question.
CBN - Cannabinol
CBN is a mildly psychoactive compound found in marijuana and is very unique to the plant. Also, like most cannabis components, CBN is fat-soluble and not water-soluble. It has a special connection with THC because, compared to other molecules, CBN does not come directly from the hemp plant. It is created by the external oxidation of THC. In other words, THC is converted to CBN during degradation .
- CBN affects specific immune cells, promotes anti-inflammatory effects and affects the levels of other compounds that cause inflammation.
- It has very weak psychoactive effects, and is also probably a better choice for increasing appetite than THC.
- The regeneration of damaged tissues and bone fractures is much faster. Can help with bone healing as it extracts the stem cells from the bone marrow.
- Relief of chronic pain
- Antibacterial
- Psoriasis – can help ease the course and relieve skin symptoms
- CBN may also be useful for people with glaucoma
